[Google Scholar]Nusse R, and Clevers H (2017). by the macropinocytosis inhibitors EIPA or IPA-3, suggesting that increases in membrane trafficking drive lysosomal activity. TH5487 Graphical Abstract In Brief Albrecht et al. show that macropinocytosis is TH5487 triggered by GSK3 inhibition or mutation of the tumor suppressor Axin1. Wnt-regulated macropinocytosis leads to acidification and FGD4 activation … Continue reading [Google Scholar]Nusse R, and Clevers H (2017)